منابع مشابه
Long-range gene regulation and novel therapeutic applications.
An intimate relationship exists between nuclear architecture and gene activity. Unraveling the fine-scale three-dimensional structure of the genome and its impact on gene regulation is a major goal of current epigenetic research, one with direct implications for understanding the molecular mechanisms underlying human phenotypic variation and disease susceptibility. In this context, the novel re...
متن کاملSumoylation in gene regulation, human disease, and therapeutic action
Similar to ubiquitination, sumoylation covalently attaches a small ubiquitin-like modifier (SUMO) protein (92-97 amino acids) to the ε-amino group of a lysine residue. This is quite different from the classically defined post-translational modifications, such as phosphorylation, acetylation, and methylation, which typically add a small chemical group to the targeted residue. Sumoylation has bee...
متن کاملBlood Spotlight Long-range gene regulation and novel therapeutic applications
Fundamental, yet unanswered, questions in biology are how genome organization and chromosomal folding influence basic cellular processes such as transcription, how they relate to the development of disease, and whether they can bemanipulated therapeutically. In mammals, gene regulatory elements are scattered throughout the genome, collectively occupying a significant fraction of the genomic non...
متن کاملDown Regulation of Osteocalcin Gene in Chickens Treated with Cadmium
Background: Cadmium is one of the heavy metals with harmful effects on different body organs and systems. The aim of this study was to investigate the harmful effects of cadmium, as a heavy metal, on the histological structure of bone and the expression of osteocalcin gene. Methods: Forty chickens were obtained, anesthetized and their femurs were surgically removed. The real time polymerase ch...
متن کاملRoles of Chromatin insulators in gene regulation and diseases
With advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. Long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. Chromatin insulators are key determinants of proper gene regulation and precise organization of c...
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ژورنال
عنوان ژورنال: Circulation
سال: 2007
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.106.685255